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George Noutsios

George Noutsios

Assistant Research Professor, School of Mathematics and Natural Sciences, New College of Interdisciplinary Arts and Sciences

Noutsios@asu.edu

School of Mathenatical and Natural Sciences
Arizona State University, West campus
4701 W. Thunderbird Rd.CLCC 310A1
Phoenix, AZ 85306

Titles

  • Senior Sustainability Scientist, Global Institute of Sustainability and Innovation
  • Assistant Research Professor, School of Mathematics and Natural Sciences, New College of Interdisciplinary Arts and Sciences

Biography

George T. Noutsios was born and raised in Thessaloniki, Greece, has a bachelor's degree in chemistry, a master's degree in biochemistry and a doctorate in biochemistry and molecular biology from Aristotle University of Thessaloniki. His dissertation focused on immobilization of antigenic biomolecules in bio-polymeric substrates for detection and diagnosis of endemic Brucella melitensis biotypes. In 2011 he came to the U.S. to pursue his career in respiratory diseases research. During his postdoctoral work at Penn State Hershey Medical Center (2011-2016) he studied the role of cis-acting elements and trans-acting factors on splicing and translation of the pulmonary surfactant protein A, and he identified 14-3-3 isoforms and microRNAs as translational regulatory molecules in lung diseases. He joined University of Arizona in 2016 where he was involved in a collaborate effort to unveil the primary mechanisms of chronic sinusitis in upper airway diseases utilizing in vivo and in vitro air-liquid interface models. Noutsios joined Arizona State University in 2018 as an assistant research professor, where he conducts his own independent research, which is extramurally funded. His focus is to decipher the role of surfactant protein A in upper airway disease and its potential as therapeutic in bacterial sinusitis. At ASU he has multiple roles: teaching microbiology as a guest lecturer, managing Dean Sandrin’s research lab and participating in a multidisciplinary team that is using molecular biology, environmental microbiology, metaproteomics, genomics and microbiome approaches to elucidate fundamental questions in human health and disease. Noutsios maintains active collaborative relationships with academic and clinical institutions across the country (PSU, UA, ASU and Mayo Clinic) in an effort to translate basic scientific findings in a laboratory setting into potential treatments for human disease. In his spare time, George enjoys cycling, working out, traveling, trying new cuisines and craft beer

Education

  • PhD, Molecular Biology, Aristotle University of Thessaloniki, 2009
  • MSc, Biochemistry, Aristotle University of Thessaloniki, 2006
  • BSc, Chemistry, Aristotle University of Thessaloniki, 2004

Expertise

Journal Articles

2019

Noutsios, G. T. and S. Saurabh. 2019. Chronic rhinosinusitis in unified airway disease: surfactant proteins as mediators of respiratory immunity. Swiss Medical Weekly 149:w20104. DOI: 10.4414/smw.2019.20104. (link )

Noutsios, G. T., N. Thorenoor, X. Zhang, D. S. Phelps, T. M. Umstead, F. Durrani and J. Floros. 2019. Major effect of oxidative stress on the male, but not femaie, SP-A1 Type II cell miRNome. Forntiers in Immunology 10(Jul):1514. DOI: 10.3389/fimmu.2019.01514. (link )

2018

Noutsios, G. T. and A. A. Pantazaki. 2018. Biomedical applications of biopolymers in airway disease. Pneumon 31(1):24-34. (link )

Tuohy, J. M., S. R. Mueller-Spitz, C. M. Albert, S. E. Scholz-Ng, M. E. Wall, G. T. Noutsios, A. J. Gutierrez and T. Sandrin. 2018. MALDI-TOF MS affords discrimination of Deinococcus aquaticus isolates obtained from diverse biofilm habitats. Frontiers in Microbiology 9(Oct):2442. DOI: 10.3389/fmicb.2018.02442. (link )

2017

Noutsios, G. T., N. Thorenoor, X. Zhang, D. S. Phelps, T. M. Umstead, F. Durrani and J. Floros. 2017. SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: Pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved. Biology of Sex Differences 8:Art. 37. DOI: 10.1186/s13293-017-0158-2. (link )

Noutsios, G. T., A. L. Willis, J. G. Ledford and E. H. Chang. 2017. Novel role of surfactant protein A in bacterial sinusitis. IFAR: Allergy & Rhinology 7(9):897-903. DOI: 10.1002/alr.21985. (link )

2016

Chang, E. H., A. L. Willis, H. C. McCrary, G. T. Noutsios, C. H. Le, A. G. Chiu, C. J. Mansfield, D. R. Reed, S. G. Brooks, N. D. Adappa, J. M. Palmer, N. G. Cohen, D. A. Stern, S. Guerra and F. D. Martinez. 2016. Association between the CDHR3 rs6967330 risk allele and chronic rhinosinusitis. The Journal of Allergy and Clinical Immunology 139(6):P1990-1992.E2. DOI: 10.1016/j.jaci.2016.10.027. (link )

2015

Noutsios, G. T., P. Ghattas, S. Bennett and J. Floros. 2015. 14-3-3 isoforms bind directly exon B of the 5′-UTR of human surfactant protein A2 mRNA. American Journal of Physiology: Lung Cellular and Molecular Physiology 309(2):L147-L157. DOI: 10.1152/ajplung.00088.2015. (link )

Noutsios, G. T., P. Ghattas, S. Bennett and J. Floros. 2015. Potential for therapeutic intervention in lung diseases. Atlas of Science (Dec):. (link )

2014

Noutsios, G. T. and J. Floros. 2014. Childhood asthma: Causes, risks, and protective factors; a role of innate immunity. Swiss Medical Weekly 144:w14036. DOI: 10.4414/smw.2014.14036. (link )

Silveyra, P., Z. C. Chroneos, S. L. DiAngelo, N. J. Thomas, G. T. Noutsios, N. Tsotakos, J. A. Howrylak, T. M. Umstead and J. Floros. 2014. Knockdown of Drosha in human alveolar type II cells alters expression of SP-A in culture: A pilot study. Experimental Lung Research 40(7):354-366. DOI: 10.3109/01902148.2014.929757. (link )

2013

Noutsios, G. T. and J. Floros. 2013. Highlights of early pneumonia surfactant: Research from bench to clinic. PNEUMON 26(4):1-6. (link )

Noutsios, G. T., P. Silveyra, F. Bhatti and J. Floros. 2013. Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure. American Journal of Physiology: Lung Cellular and Molecular Physiology 304(11):L722-L735. DOI: 10.1152/ajplung.00324.2012. (link )

Yang, W., L. Ni, P. Silveyra, G. Wang, G. T. Noutsios, A. Singh, S. L. DiAngelo, O. Sanusi, M. Raval and J. Floros. 2013. Motifs within the CA-repeat-rich region of Surfactant Protein B (SFTPB) intron 4 differentially affect mRNA splicing. Journal of Molecular Biochemistry 2(1):40-55. (link )

2012

Noutsios, G. T., R. M. Papi, L. V. Ekateriniadou, A. Minas and D. A. Kyriakidis. 2012. Molecular typing of Brucella melitensis endemic strains and differentiation from the vaccine strain Rev-1.. Veterinary Research Communications 36(1):7-20. DOI: 10.1007/s11259-011-9505-7. (link )