Skip to Content
Karen Watanabe

Karen Watanabe

Associate Professor, School of Mathematical and Natural Sciences, New College of Interdisciplinary Arts and Sciences

karen.watanabe@asu.edu

602-543-5811

School of Mathematical and Natural Sciences
Arizona State University, West campus
4701 W. Thunderbird Road
Glendale, AZ 85306

Titles

  • Senior Sustainability Scholar, Julie Ann Wrigley Global Institute of Sustainability
  • Associate Professor, School of Mathematical and Natural Sciences, New College of Interdisciplinary Arts and Sciences

Biography

Karen H. Watanabe, PhD is an associate professor in the School of Mathematical and Natural Sciences at Arizona State University, West campus.  She is the program lead for the Pharmacology & Toxicology BS degree.  Her research focuses on developing mathematical models of biological systems to better understand and predict how chemicals in the environment affect living organisms.  Since 2004, her research has focused upon reproductive health both under normal conditions and in response to endocrine active chemicals, and the development of adverse outcome pathway models for predictive toxicology and risk assessment.

Watanabe has received Scientific and Technological Achievement Awards from the U.S. Environmental Protection Agency for research related to modeling endocrine active chemicals and their effects upon reproduction in the context of ecological risk assessment.  She has also participated in national and international workgroups focused on adverse outcome pathways and cancer risk assessment.

Education

  • PhD, Mechanical Engineering, University of California-Berkeley, 1993
  • MS, Mechanical Engineering, University of California-Berkeley, 1990
  • BS, Chemical Engineering, Northwestern University, 1986

Expertise

Journal Articles

2019

Muller, E. B., K. Lika, R. M. Nisbet, I. R. Schultz, J. Casas, A. Gergs, C. A. Murphy, D. Nacci and K. H. Watanabe. 2019. Regulation of reproductive processes with dynamic energy budgets. Functional Ecology 33(5):819-832. DOI: 10.1111/1365-2435.13298. (link )

2018

Murphy, C. A., R. M. Nisbet, P. Antczak, N. Garcia-Reyero, A. Gergs, K. Lika, T. Mathews, E. B. Muller, D. Nacci, A. Peace, C. H. Remien, I. R. Schultz, L. M. Stevenson and K. H. Watanabe. 2018. Incorporating suborganismal processes into dynamic energy budget models for ecological risk assessment. Integrated Environmental Assessment and Management 14(5):615=624. DOI: 10.1002/ieam.4063.. (link )

Nishimura, J., R. Smith, K. Jensen, G. T. Ankley and K. H. Watanabe. 2018. Estimating intermittent individual spawning behavior via disaggregating group data. Bulletin of Mathematical Biology 80(3):687-700. DOI: 10.1007/s11538-017-0379-x. (link )

Rowland, M. A., H. Wear, K. H. Watanabe, K. A. Gust and M. L. Mayo. 2018. Statistical relationship between metabolic decomposition and chemical uptake predicts bioconcentration factor data for diverse chemical exposures. BMC Systems Biology 12:Art. 81. DOI: 10.1186/s12918-018-0601-y. (link )

2017

Conolly, R. B., G. T. Ankley, W. Cheng, M. L. Mayo, D. H. Miller, E. J. Perkins, D. L. Villeneuve and K. H. Watanabe. 2017. Quantitative adverse outcome pathways and their application to predictive toxicology. Environmental Science & Technology 51(8):4661-4672. DOI: 10.1021/acs.est.6b06230. (link )

Wear, H. M., A. Eriksson, H. H. Yao and K. H. Watanabe. 2017. Cell-based computational model of early ovarian development in mice. Biology of Reproduction 97(3):365-377. DOI: 10.1093/biolre/iox089. (link )

2016

Watanabe, K. H., M. Mayo, K. M. Jensen, D. L. Villeneuve, G. T. Ankley and E. J. Perkins. 2016. Predicting fecundity of fathead minnows (Pimephales promelas) exposed to endocrine-disrupting chemicals using a MATLAB®-based model of oocyte growth dynamics. PLOS One 11(1):e0146594. DOI: 10.1371/journal.pone.0146594. (link )

Wear, H. M., M. J. McPike and K. H. Watanabe. 2016. From primordial germ cells to primordial follicles: A review and visual representation of early ovarian development in mice. Journal of Ovarian Research 9(Art 36):. DOI: 10.1186/s13048-016-0246-7. (link )

2015

Groh, K. J., R. N. Carvalho, J. K. Chipman, N. D. Denslow, M. Halder, C. A. Murphy, D. Roelofs, A. Rolaki, K. Schirmer and K. H. Watanabe. 2015. Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. Challenges and research needs in ecotoxicology. Chemosphere 120(Feb):764-777. DOI: 10.1016/j.chemosphere.2014.09.068. (link )

Groh, K. J., R. N. Carvalho, J. K. Chipman, N. D. Denslow, M. Halder, C. A. Murphy, D. Roelofs, A. Rolaki, K. Schirmer and K. H. Watanabe. 2015. Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. A focus on growth impairment in fish. Chemosphere 120(Feb):778-792. DOI: 10.1016/j.chemosphere.2014.10.006. (link )

2013

Breen, M., D. L. Villeneuve, G. T. Ankley, D. C. Bencic, M. S. Breen, K. H. Watanabe, A. L. Lloyd and R. B. Conolly. 2013. Developing predictive approaches to characterize adaptive responses of the reproductive endocrine axis to aramatase inhibition: II. Computational modeling. Toxicological Sciences 133(2):234-247. DOI: 10.1093/toxsci/kft067. (link )

2012

Villeneuve, D. L., N. Garcia-Reyero, D. Martinovic-Weigelt, Z. Li, K. H. Watanabe, E. F. Orlando, C. A. LaLone, S. W. Edwards, L. D. Burgoon, N. D. Denslow, E. J. Perkins and G. T. Ankley. 2012. A graphical systems model and tissue-specific functional gene sets to aid transcriptomic analysis of chemical impacts on the female teleost reproductive axis. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 746(2):151-162. DOI: 10.1016/j.mrgentox.2011.12.016. (link )

2011

Johns, S. M., N. D. Denslow, M. D. Kane, K. H. Watanabe, E. F. Orlando and M. S. Sepulveda. 2011. Effects of estrogens and antiestrogens on gene expression of fathead minnow (Pimephales promelas) early life stages. Environmental Toxicology 26(2):195-206. DOI: 10.1002/tox.20545. (link )

Li, Z., K. J. Kroll, K. Jensen, D. L. Villeneuve, G. T. Ankley, J. V. Brian, M. S. Sepulveda, E. F. Orlando, J. M. Lazorchak, M. Kostich, B. Armstrong, N. D. Denslow and K. H. Watanabe. 2011. A computational model of the hypothalamic-pituitary-gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol and 17β-trenbolone. BMC Systems Biology 5:Art. 63. DOI: 10.1186/1752-0509-5-63. (link )

Li, Z., D. L. Villeneuve, K. M. Jensen, G. T. Ankley and K. H. Watanabe. 2011. A computational model for asynchronous oocyte growth dynamics in a batch-spawning fish. Canadian Journal of Fisheries and Aquatic Sciences 68(9):1528-1538. DOI: 10.1139/f2011-066. (link )

Watanabe, K. H., M. E. Andersen, N. Basu, M. J. Carvan III, K. M. Crofton, K. A. King, C. Sunol, E. Tiffany-Castiglioni and I. R. Schultz. 2011. Defining and modeling known adverse outcome pathways: Domoic acid and neuronal signaling as a case study. Environmental Toxicology and Chemistry 30(1):9-21. DOI: 10.1002/etc.373. (link )

2009

Ankley, G. T., D. C. Bencic, M. S. Breen, T. W. Collette, R. B. Conolly, N. D. Denslow, S. W. Edwards, S. Ekman, N. Garcia-Reyero, K. M. Jensen, J. M. Lazorchak, D. Martinovic-Weigelt, D. H. Miller, E. J. Perkins, E. F. Orlando, D. L. Villeneuve, R. Wang and K. H. Watanabe. 2009. Endocrine disrupting chemicals in fish: Developing exposure indicators and predictive models of effects based on mechanism of action. Aquatic Toxicology 92(3):168-178. DOI: 10.1016/j.aquatox.2009.01.013. (link )

Garcia-Reyero, N., K. J. Kroll, L. Liu, E. F. Orlando, K. H. Watanabe, M. S. Sepulveda, D. L. Villeneuve, E. J. Perkins, G. T. Ankley and N. D. Denslow. 2009. Gene expression responses in male fathead minnows exposed to binary mixtures of an estrogen and antiestrogen. BMC Genomics 10:Art. 308. DOI: 10.1186/1471-2164-10-308. (link )

Garcia-Reyero, N., D. L. Villeneuve, K. J. Kroll, L. Liu, E. F. Orlando, K. H. Watanabe, M. S. Sepulveda, G. T. Ankley and N. D. Denslow. 2009. Expression signatures for a model androgen and antiandrogen in the fathead minnow (em>Pimephales promelas ovary. Environmental Science & Technology 43(7):2614-2619. DOI: 10.1021/es8024484. (link )

Johns, S. M., M. D. Kane, N. D. Denslow, K. H. Watanabe, E. F. Orlando, D. L. Villeneuve, G. T. Ankley and M. S. Sepulveda. 2009. Characterization of ontogenetic changes in gene expression in the fathead minnow (Pimephales promelas). Environmental Toxicology and Chemistry 28(4):873-880. DOI: 10.1897/08-213R.1. (link )

Watanabe, K. H., M. V. Djordjevic, S. D. Stellman, P. L. Toccalino, D. F. Austin and J. F. Pankow. 2009. Incremental lifetime cancer risks computed for benzo[a]pyrene and two tobacco-specific N-nitrosamines in mainstream cigarette smoke compared with lung cancer risks derived from epidemiologic data. Regulatory Toxicology and Pharmacology 55(2):123-133. DOI: 10.1016/j.yrtph.2009.06.007. (link )

Watanabe, K. H., Z. Li, K. J. Kroll, D. L. Villeneuve, N. Garcia-Reyero, E. F. Orlando, M. S. Sepulveda, T. W. Collette, D. R. Ekman, G. T. Ankley and N. D. Denslow. 2009. A computational model of the hypothalamic-pituitary-gonadal axis in male fathead minnows exposed to 17α-ethinylestradiol and 17β-estradiol. Toxicological Sciences 109(2):180-192. DOI: 10.1093/toxsci/kfp069. (link )

2007

Pankow, J. F., K. H. Watanabe, P. L. Toccalino, W. Luo and D. F. Austin. 2007. Calculated cancer risks for conventional and "potentially reduced exposure product" cigarettes. Cancer Epidemiology, Biomarkers & Prevention 16(3):584-592. DOI: 10.1158/1055-9965.EPI-06-0762. (link )

Watanabe, K. H., K. M. Jensen, E. F. Orlando and G. T. Ankley. 2007. What is normal? A characterization of the values and variability in reproductive endpoints of the fathead minnow, Pimephales promelas. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 146(3):348-356. DOI: 10.1016/j.cbpc.2007.04.015. (link )

2006

Luna, R., K. H. Watanabe and A. J. Wilding. 2006. Spatial bioaccumulation modeling in a network of bayous. Environmental Modelling & Software 21(12):1674-1683. DOI: 10.1016/j.envsoft.2005.08.003Get. (link )

2005

Watanabe, K. H., H. Lin, H. L. Bart Jr, P. Martinat, J. C. Means, M. L. Kunas and D. A. Grimm. 2005. Bayesian estimation of kinetic rate constants in a food-web model of polycyclic aromatic hydrocarbon bioaccumulation. Ecological Modelling 181(2-3):229-246. DOI: 10.1016/j.ecolmodel.2004.06.040. (link )

2004

Lin, H., D. W. Berzins, L. Myers, W. J. George, A. Abdeighani and K. H. Watanabe. 2004. A Bayesian approach to parameter estimation for a crayfish (Procambarus spp): Bioaccumulation model. Environmental Toxicology and Chemistry 23(9):2259-2266. DOI: 10.1897/03-303. (link )

2003

Watanabe, K. H., F. W. Desimone, A. Thiyagarajah, W. R. Hartley and A. E. Hindrichs. 2003. Fish tissue quality in the lower Mississippi River and health risks from fish consumption. Science of the Total Envirronment 302(1-3):109-126. DOI: 10.1016/S0048-9697(02)00396-0. (link )

2000

Bollinger, J. E., L. J. Steinberg, A. J. Englande, J. P. Crews, J. M. Hughes, C. Velasco, K. H. Watanabe, W. R. Hartley, C. M. Swaim, J. M. Mendler, L. E. White and W. J. George. 2000. Nutrient load characterization from integrated source data for the lower Mississippi River. Journal of the American Water Resources Association 36(5):1375-2390. DOI: 10.1111/j.1752-1688.2000.tb05733.x. (link )

1997

Watanabe, K. H. and C. C. Travis. 1997. Mathematical modeling of skin papilloma data in SENCAR mice. Toxicology and Applied Pharmacology 147(2):419-430. DOI: 10.1006/taap.1997.8286. (link )

1996

Watanabe, K. H. and F. Y. Bois. 1996. Inerspecies extrapolation of physiological pharmokinetic parameter distributions. Risk Analysis 16(6):741-754. (link )

1994

Li, H., K. H. Watanabe, D. M. Auslander and R. C. Spear. 1994. Model parameter estimation and analysis: Understanding parametric structure. Annals of Biomedical Engineering 22(1):97-111. DOI: 10.1007/BF023682. (link )

Watanabe, K. H., F. Y. Bois, J. M. Daisey, D. M. Auslander and R. C. Spear. 1994. Benzene toxicokinetics in humans: exposure of bone marrow to metabolites. Occupational & Environmental Medicine 51(6):414-420. DOI: 10.1136/oem.51.6.414. (link )

1992

Watanabe, K. H., F. Y. Bois and L. Zeise. 1992. Interspecies extrapolation: A reexamination of acute toxicity data. Risk Analysis 12(2):301-310. DOI: 10.1111/j.1539-6924.1992.tb00677.x. (link )

Book Chapters

In Press

Watanabe, K. H., H. Aladjov, S. A. Bell, W. Cheng, R. B. Conolly, S. W. Edwards, N. Garcia-Reyero, M. L. Mayo, A. Schroeder, C. Wittwehr and E. J. Perkins. Big data integration and inference. In: Neagu, D. and A. Richarz eds., Big Data in Predictive Toxicology. Royal Society of Chemistry. ISBN: 978-1782622987.

2018

Murphy, C. A., R. M. Nisbet, P. Antczak, N. Garcia-Reyero, A. Gergs, K. Lika, T. Mathews, E. B. Muller, D. Nacci, A. L. Peace, C. H. Remien, I. R. Schultz and K. H. Watanabe. 2018. Linking adverse outcome pathways to dynamic energy budgets: A conceptual model. Pp. 281-302 In: Garcia-Reyero, N. and C. A. Murphy eds., A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment. Springer International Publishing. ISBN: 978-3-319-66082-0.

Schultz, I. R. and K. H. Watanabe. 2018. The development of quantitative AOPs. Pp. 263-280 A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment. Springer Internatinal Publishing. ISBN: 978-3-319-66082-0.

2009

Watanabe, K. H. and H. Lin. 2009. Bayesian approaches to characterise uncertainty and variability in biological and environmental models and risk assessment. Pp. 219-240 In: Hanrahan, G. ed., Modelling of Pollutants in Complex Environmental Systems. Vol I. ILM Publications. Hertfordshire, UK. ISBN: 978-1906799007.

2005

Watanabe, K. H. 2005. Modeling exposure and target organ concentrations. Pp. 115-124 In: Edler, L. and C. Kitsos eds., Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment. John Wiley & Sons. Chichester, West Sussex, UK. ISBN: 978-0-470-85756-4.

1999

Amaral-Mendes, J. J., V. J. Cogliano, A. Kappas, C. Kitsos, E. D. Kroese, E. G. Luebeck, E. Pluygers, C. Travis, K. Watanabe, W. Wosniok and G. A. Zapponi. 1999. Conclusions and recommendations. Pp. 309-314 In: Cogliano, V. J., E. G. Luebeck and G. A. Zapponi eds., Perspectives on Biologically Based Cancer Risk Assessment. Springer. ISBN: 978-0-306-46108-8.

Kappas, A., V. J. Cogliano, K. Watanabe and G. A. Zapponi. 1999. Sources of data for cancer risk assessment. Pp. 49-80 In: Cogliano, V. J., E. G. Luebeck and G. A. Zapponi eds., Perspectives on Biologically Based Cancer Risk Assessment. Springer US. ISBN: 978-0-306-46108-8.

Luebeck, E. G., C. Travis and K. Watanabe. 1999. Informative case studies. Pp. 275-308 In: Cogliano, V. J., E. G. Luebeck and G. A. Zapponi eds., Perspectives on Biologically Based Cancer Risk Assessment. Springer. ISBN: 978-0-306-46108-8.

Wosniok, W., C. Kitsos and K. Watanabe. 1999. Statistical issues in the application of multistage and biologically based models. Pp. 243-273 In: Cogliano, V. J., E. G. Luebeck and G. A. Zapponi eds., Perspectives on Biologically Based Cancer Risk Assessment. Springer. ISBN: 978-0-306-46108-8.